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Ibutamoren (MK-677, L-163,191) is a drug which acts as a potent, orally active growth hormone secretagogue,mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults,and human studies have shown it to increase both muscle mass and bone mineral density,making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.Scientific study that has been based on animal test subjects has determined that MK-677 has slightly different properties than other secretogogues such as GHRP-6. This determination was not always the case, as it was previously thought that it was indistinguishable in vitro and in vivo from a functionality standpoint. Yet it was determined after oral administration in animal test subjects, which activates the catalog chemical, it was significantly more efficacious than other secretogogues, putting forth a mean peak GH concentration of 22.1 μg/L based on an oral dosage of 25 mg.